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In addition, indoxyl sulfate raises levels of proalpha1(I) collagen, tissue inhibitor of metalloproteinase-1, transforming growth factor-beta1, and free radicals in vascular endothelium and smooth muscle cells

Glutathione is a crucial antioxidant found in all body cells and plays a fundamental role in neutralizing free radicals and protecting cells from oxidative damage

This finding indicates that MTH1 is regulated by upstream genes and elucidates a mechanism in TNBC development (Zhang et al., 2020b)

In: NoebelsJLAvoliMRogawskiMAOlsenRWDelgado-EscuetaAV, editors