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Studies published in Nature and Diabetes journals have shown NNMT expression levels correlate with adipocyte hypertrophy and reduced insulin signalling

There is also recent data which suggest that genetic alterations of the receptor by which B12 is transported into nerve tissue and the brain, may lead to a lower B12 uptake

doi: 10.1038/nature10350

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a novel small molecule peptide classified as an NNMT inhibitor meaning it blocks the activity of the enzyme nicotinamide N-methyltransferase (NNMT), which plays a key role in cellular energy metabolism , fat storage , and aging

Alternatives: Are there better-established options for what I am trying to achieve