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14hj), reminiscent of the intestinal degeneration previously observed in mated hermaphrodites 57

Its different effects on lipoprotein metabolism with a possible role in the modulation of inflammation makes the net impact of apoC1 on cardiometabolic risk difficult to figure out and apoC1 might be considered as pro-atherogenic or anti-atherogenic depending on the overall metabolic context

10.1161/atvbaha.107.142455

Overall, the therapeutic potential of L-carnitinebased combination strategies is most likely to be maximized when they are tailored to specific pathological contexts and concurrently target key processes such as fatty acid oxidation, insulin signaling, oxidative stress, and gut barrier integrity (92)