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Consistent with the observations in 2D cell lines, treatment with PH755 alone did not impact the growth of Apc or Apc/Kras organoids
General guidelines for new medications consider a 20% reduction to be clinically meaningful 12 , which requires a minimum sample size of 41, at alpha = 0.05 and 90% power
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Mol Cell 54(1):133146 Wang M et al (2019) Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA
Shelf life: 3 years
