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Activation of ERK is dependent on the RAS/MAPK pathway, in which IIS results in phosphorylated IRS or SHC that recruit growth factor receptor-bound protein 2 (GRB-2)

Gupton-Campolongo T

[(1) One patent Issued (3/20/12) Lipidomic approaches to determine drug response phenotypes in cardiovascular disease Patent # 8137977, expires 12/10/27

Such bacteria include Lachnospiraceae FCS020 and Porphyromonas bennonis

They found that this process, called desialylation, triggers CAR-iMac cells to become activated and more effective at killing cancer cells
