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10.3389/fnmol.2018.00070 Front
As a result, most good plant antioxidants are unable to achieve the desired outcome because they generally have low bioavailability and some can exert pro-oxidant effects under in vivo conditions [79,80]
Furthermore, flavokavains A and B were shown to have immunomodulatory functions, such as the stimulation of splenocyte proliferation and the secretion of IL-2 and TNF- in harvested splenocytes, as well as an increase in the subsets of T cell populations in BALB/c mice, with flavokavain B being more potent than flavokavain A (30 g/mL) [59]
