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American Journal of Clinical Nutrition 1994;60(1):211
Supplementing with vitamin B12 is generally considered safe, as there is a low risk of toxicity
Also, pyruvate dehydrogenase kinase isoenzyme-4 encodes pyruvate dehydrogenase complex (PDK)
Deficiency may present as fatigue, neuropathy, cognitive changes, or gastrointestinal symptoms related to malabsorption
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