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These models highlight distinct pathological and temporal features of AD, including early synaptic changes and amyloid accumulation, providing valuable tools for studying disease progression and potential therapeutic targets

One allele is typically normal-sized compared to healthy individuals [89], whilst the other allele contains fragments ( 43 kb) after Eco RI cleavage and fragments ( 40 kb) after Eco RI and Bln I double digestion

In addition to coordination symptoms, despite FRDA being primarily a neurological condition, patients also exhibit diabetes and hypertrophic cardiomyopathy, which are the primary cause of premature death [2,4]

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Lipid ROS- and iron-dependent ferroptotic cell death in unicellular algae Chlamydomonas reinhardtii