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This phenomenon, called aerobic glycolysis or the Warburg effect, has been exploited for visualizing tumors in the clinical setting by imaging their uptake of the radiolabeled glucose analog, [18F] fluoro-2-deoxyglucose (FDG), via Positron Emission Tomography (PET)

Metformin directly inhibits mitochondrial electron transport chain complex I and subsequently induces protective autophagy in the liver through the AMPKmTORC1 signaling axis, effects that extend lifespan in animal models and are associated with a reduced risk of metabolic syndrome, cardiovascular disease, and cancer in human populations (Madeo et al., 2019)

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For more on keeping vitamin levels up, even if youre on meds like metformin, check out Mayo Clinics guide to vitamin B12