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For example, Bisphenol A (BPA) and formaldehyde are the widespread environmental pollutants, both of which can cause male reproductive injuries including testicular histopathological changes (decreased spermatogenic cells (144) or testicular tissue necrosis and edema (145)), testicular oxidative stress damage(reducing testicular antioxidant enzyme activity (197)) and cells apoptosis(up-regulating Bax apoptotic protein expression (145))

Relationship to contractile performance

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Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas