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Anaemia in kidney disease: harnessing hypoxia responses for therapy

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Relevant to understanding the role of GPx-1 in mediating cell signaling, modest (approximately twofold) overexpression of GPx-1 in permanently transfected cells was found to be sufficient to decrease accumulation of intracellular ROS and attenuate EGFR-mediated signal transduction in response to hydrogen peroxide or its cognate ligand, EGF

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Discovery and Research History (Pickart, 1973Present) Pickart's foundational observation was that plasma from young donors caused liver cells from older donors to behave more like young tissue