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These perivascular spaces of the penetrating arterioles, precapillary arterioles, postcapillary venules, and venules separate the glial and vascular BMs and are a low resistance highway for CSF influx into the brain parenchyma (Yamamoto et al, 2024)

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Specifically, PI3K functions as a key intracellular signaling mediator downstream of the CXCR2/CXCL8 axis within the PI3K/Akt signaling pathway

Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 3,4,5