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Assay: Activity is monitored by uric acid formation (295 nm) or by the Amplex Red assay

Erratum in Pharmaceutics 2022, 14, 499

In the context of impaired glutathione metabolism, two converging factors promote PGA accumulation

Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences