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Primary end points also included hospitalization and oxygen requirements, with severity parameters defined by CDC pneumonia criteria (18)

These alterations are closely linked to subtle changes in glomerular filtration barrier permeability and impaired OCTN2-mediated tubular reabsorption, reflecting an early breakdown of the filtration, reabsorption, redistribution balance of carnitine metabolism

This interference of plasminogen binding leads to reduced surface-dependent activation of plasminogen to plasmin

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Kennedy, David O, et al