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Therefore, based on TCM and Western medicine, the liver has the bidirectional relationships with the extrahepatic organs, and the established bidirectional system by the liver and one extrahepatic organ can further influence another one or more extrahepatic organs or tissues, thus, form a single line or multidimensional interaction network centered on the liver, which has been depicted as the pan-liver network. We propose these complex network mechanisms as the pan-liver network theory, in this theory, the liver plays an essential role in modulating health and diseases through multiple signals

In humans, AMPK-mediated HMGCR Ser872 phosphorylation inhibits the activity of HMGCR and decreases cholesterol production 67

Abstract Iron, an essential mineral in the body, is involved in numerous physiological processes, making the maintenance of iron homeostasis crucial for overall health

There was 100% agreement among pathologists in classifying low and high malignancy MCT [80]

This promotes thioldisulfide exchange reactions at physiological pH conditions [181]