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In addition to the catalytic function of PCBD1, the protein serves as a transcriptional co-activator for two transcription factors of the hepatocyte nuclear factor-1 family, HNF-1 (encoded by the HNF1A gene) and HNF-1 (encoded by the HNF1B gene)

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Nagatsu et al

Non-responders had elevated levels of proteins associated with processes of hematopoietic and cell death, whereas responders had overexpression in proteins linked to myeloid cell activation, neutrophil degranulation, and M phase regulation