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Even though the link between ADE of infection and disease severity is yet to be established, in the past, the severity of infection and cross-reactivity of antibodies to other viral serotypes have been linked and established in vitro for Zika, Dengue, and Influenza A viral infection 28,29,30

The underlying mechanism may be related to GSH metabolism (163), abnormal iron metabolism (164), lipid peroxidation (165) and mitochondrial dysfunction (166)

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