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Meanwhile, synthetic polymer materials, though tunable in mechanical performance and degradation via molecular design and composite engineering, suffer from poor cell recognition and limited bioactivity (Brinkmann et al., 2023

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Moreover, the method is robust, since it can be adapted to different feeder models, and the model can be trained via a synthetic data set and still achieves desirable performance in real-world measurement

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The trial-product estimand is closer to as-treated: it estimates the effect if participants stayed on treatment as intended