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22 This inhibition reduces the local inflammatory response, creating a more conducive environment for tissue regeneration by limiting the recruitment of inflammatory cells that could otherwise contribute to tissue damage

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PMID: 27778306 Richie JP Jr, et al

10.1007/s00248-015-0669-5 Microb

FIGURE 2 On the other hand, in addition to its well-known functions, PGC1, a master regulator of mitochondrial biogenesis, positively regulates mitophagy by directly inducing the expression of transcription factor EB (TFEB) that mediates lysosomal biogenesis (Settembre et al., 2011)