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The transplantation of HLA (human leukocyte antigen)-matched sibling donor (MSD) cells into young class 1 or class 2 individuals on myeloablative conditioning (14 mg/kg busulfan + 200 mg/kg cyclophosphamide) and cyclosporin for graft-versus-host disease (GVDH) prophylaxis, gave excellent results (8290% disease-free survival), but this treatment was highly toxic in pediatric class 3 patients (only 55% survived) [78], [79]

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Anyone pregnant or breastfeeding, given the total absence of safety data in that population

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Always check labels to calculate total daily intake and consult your GP if unsure

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Most people will notice the benefits of B12 injections within three to four sessions (even following the first session)

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