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52,53 Based on this preliminary safety and efficacy data, a first-in-human phase 1/2 human clinical trial with the recombinant AAV8 vector AAV8.TBG.hLDLR commenced in 2016 (ClinicalTrials.gov Identifier: NCT02651675)

Exercise-Activated mPFC Tri-Synaptic pathway ameliorates Depression-Like behaviors in mouse

Results: Hepatic expression of PPAR was significantly decreased in DILI patients

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