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This conversion creates a recycling pathway known as the citrulline-NO cycle, where NOS (nitric oxide synthase) enzymes transform L-arginine into NO and L-citrulline

Poindessous et al., 2024)

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These were cells of sod1 and sod2 strains without activity of superoxide dismutases enzymes which scavenge superoxide anion radical from the cytoplasm and mitochondrial matrix, respectively, as well as strains lacking activity of Msn2p and Msn4p, which activate the environmental stress response programme