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LPS administration was shown to reduce hepatic GSH protein levels, which is known as a highly effective intracellular antioxidant first-line defense against free radicals and plays a key role in determining how susceptible tissue is to oxidative damage []

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases

doi: 10.1073/pnas.1001006107 41 LiuJZhangCWangJHuWFengZ

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Thus, in terms of ageing, an inverse trend may exist for the two types of Drosophila nephrocytes, whereby the PNCs progressively lose their ability to degrade sequestered material from the haemolymph, while the GNCs gradually increase this capacity