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Acute ischaemic stroke mixed, leaning cautious The 2023 Cochrane review found no clear clinical benefit and a moderate-certainty signal of more non-fatal serious adverse events

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These ROS oxidize PUFAs in cell membranes into lipid peroxides (PUFA-OOH), thereby destroying cell membrane structural stability, attacking cellular DNA and proteins, and causing ferroptosis

Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of Guinea-pig submucosal neurons
