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However, the course of treatment should be at least 6 months to obtain good results, which may have side effects, including skin atrophy, telangiectasia (spider vein, dilation of blood vessels), and acneiform eruptions (in this case, it is advisable to switch to topical immunomodulators)

Another early investigation published in the European Journal of Endocrinology documented that, unlike older GH-releasing peptides, such as GHRP-2 or GHRP-6, ipamorelins GH stimulation is highly selective and does not significantly increase cortisol or prolactin levels, suggesting a cleaner hormonal profile with fewer off-target endocrine effects compared to earlier secretagogues

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Zhang ZY, Hong D, Nam SH, Kim JM, Paik YH, Joh JW, Kwon CH, Park JB, Choi GS, Jang KY, Park CK, Kim SJ