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Among the most relevant studies, Bay and colleagues developed a novel blood-based diagnostic panel (HepaClear), which combined methylation analysis of three gene-related CpG sites with AFP and des-gamma-carboxyprothrombin (DCP) protein markers [190]

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Increased ROS production and/or reduced antioxidant defenses lead to the accumulation of dysfunctional proteins, lipids and nucleic acids (including mtDNA) and impaired mitophagy

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Regulation of heterochromatic silencing and histone H3 lysine 9 methylation by RNAi