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Some protein tags even improve the solubility of target proteins, making them easier to work with, or change other properties such as a proteins localization or degradation in cells

This shortage further manifested as downregulation of beta cell identity genes and a tonic increase in endoplasmic reticulum stress markers, which resulted in diminished insulin secretion both in vitro and in vivo

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One study showed a significant correlation between the levels of chlorogenic acid lactones in coffee and neuron cell survival