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Down regulation of ACE (ACE degrades BKN) by estrogen combined with a viral infection can supercharge BKN

manufactured by Diagen, d.o.o., Ljubljana, Slovenia) (9-11, 13-24), morphine Merck 20 (Merck KGaA, Darmstadt, Germany), naloxone hydrochloride (Sigma-Aldrich, Germany), haloperidol (Sigma-Aldrich, Germany) were used