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Evidence of severe nerve damage on diagnostic tests

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consequently creating a cellular oxidative environment which triggers the oxidation of essential biomolecules like DNA, protein and lipids, leading to multiple disease conditions

Postsynaptic receptor activation mediates phasic inhibition, whereas extrasynaptic activation mediates a tonic inhibitory state [65, 69]

Reiniers MJ, van Golen RF, van Gulik TM, Heger M (2014) Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver