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Clinical Evidence: Several studies support the potential of BPC-157 in correcting calcium imbalance: a) A study published in the Journal of Orthopaedic Research demonstrated that BPC-157 administration improved bone healing and increased calcium deposition in rats with induced bone fractures, suggesting its positive effect on calcium metabolism

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On the other hand, there is evidence that spinal cord injury triggers a cascade of secondary degenerative events that cause further damage to the injured area and induce local inflammation along with hemorrhage and edema [12, 13] and that the therapeutic agents imatinib (which has been shown to inhibit cytokine production and reduce hemorrhage, edema, and inflammation) [14] and ibuprofen initiate favorable axonal growth and functional recovery through Rho inhibition [15]

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The open-label design of REDEFINE 4 is worth noting