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Here, we report a case of systemic contact dermatitis arising from the cobalt in methylcobalamin, characterized by palmoplantar eczema with histopathological T-cell lymphomatoid reaction.A 59-year-old Japanese female [...]

Conclusion: Sublingual and oral B12 supplementation appear to be as effective as intramuscular (IM) injections in improving cobalamin status and reducing homocysteine levels

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Numbness and tingling (peripheral neuropathy) or brain fog do not appear until the final stage