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Another study has indicated that TcdB from epidemic NAP1/RT027 strains induced the dysfunctional stem cell state in both mice and human colonic organoids without binding to FZD1/2/7, instead it maintained the ability to interact with CSPG4 and Nectin-3 (Mileto et al., 2020)

It doesn't strongly influence appetite or sexual function because it largely ignores the MC3R and MC4R receptors in the brain

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While azelaic acid can be quite unstable, the one used in skincare products is largely lab-engineered and hence is comparatively more stable and effective