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[DOI] [PMC free article] [PubMed] [Google Scholar] 96

Topical bioavailability: Lower but meaningful

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The ability of integrins to act as a bridge between the extracellular environment and cytoskeleton/signal protein kinases enables them to transmit inside-out and outside-in signals and to mediate both bidirectional force transmission and signal transduction via an allosteric mechanism by switching between active and inactive conformations [35, 36]