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As an acetylated form of L-Carnitine, Acetyl L-Carnitine (ALC or ALCAR) is a naturally occurring amino acid derivative that stands out for its enhanced ability to cross the blood-brain barrier

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First, antioxidant properties allow alpha-lipoic acid to neutralize free radicals and reduce oxidative stress, which is linked to damage that can increase heart disease risk ( Second, its been shown to improve endothelial dysfunction a condition in which blood vessels cannot dilate properly, which also raises the risks of heart attack and stroke ( Whats more, a review of studies found that taking an alpha-lipoic acid supplement lowered triglyceride and LDL (bad) cholesterol levels in adults with metabolic disease ( Summary Alpha-lipoic acid has strong antioxidant properties, which may reduce inflammation and skin aging, promote healthy nerve function, lower heart disease risk factors, and slow the progression of memory loss disorders

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Moreover, HNE is diffusible to other parts of the cell, such as mitochondria (8), and can even be carried from one brain region to another (13)

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This hypothesis is further supported by the results of bivamelagons phase II trial in patients with HO, where bivamelagon was able to achieve BMI reductions comparable to setmelanotide (NCT06046443, NCT07156578) (103, 104)

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