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This validation through rigorous clinical research distinguishes AOD-9604 from many peptides that lack comparable human data

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Ramrez-Lopera V., Uribe-Castro D., Bautista-Amorocho H., Silva-Sayago J.A., Mateus-Snchez E., Ardila-Barbosa W.Y., Prez-Cala T.L

Bozzini S., Bincoletto V., Pandolfi L., et al., Hyaluronic AcidDecorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis, Small Science 5 (2025): 2500144

However, it is debated what the role of AGE-RAGE binding is, due to the multi-ligand properties of the receptor and since the in vivo plasma ratio of AGE to RAGE would suggest a saturation of RAGE

Castello PR, Drechsel DA, Day BJ, Patel M (2008) Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins