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The rationale for excluding these trials is detailed in the supplementary material (Table S6)

This makes the standalone approach more economical for most patients

Research protocols often recommend refrigeration after reconstitution and limited use windows (e.g., 728 days depending on the compound)

References Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J et al (2024) Accurate structure prediction of biomolecular interactions with AlphaFold 3

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