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Under normal oxygen conditions, EGLNs hydroxylate the HIF subunit, which facilitates its interaction with the von Hippel-Lindau E3 ubiquitin ligase complex and ultimately leads to the proteasome degradation of the HIF subunit

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The first stage is the formation of the peptide bond between a cysteine and a glutamic acid catalyzed by -glutamylcysteine ligase (-GCL)

This is crucial context because it explains why AOD 9604 works better as part of a combination strategy rather than as a standalone fat loss solution

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