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Introduction In recent years, it has been observed that nutritional deficiencies in the diet of industrialized countries are the main risk factor for the development of various diseases, that affect the gastrointestinal tract [1,2], such as ulcerative colitis (UC) [3,4,5]

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61 Many of those experiments that had trouble finding an increase in TMAO after carnitine challenges lacked adequate timing or used only a moderate amount of red meat, whereas studies that included a significant carnitine load from red meat have shown clearer TMAO elevation

Research suggests these findings support yohimbine's role in fat mobilization during exercise

Moreover, the concentration of carnitines in biological samples is low, and complex sample preparation steps are needed to improve the sensitivity of the detection method, which however increases the analysis time