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10.1182/blood.v92.4.1191.416k15_1191_1198 [DOI] [PubMed] [Google Scholar] La Torre G., Calzoni L., Colamesta V., Guzzo A

H., Kim C.-B., Noh S

B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease

High NNMT activity has also been linked to: Poor mitochondrial function Increased oxidative stress Accelerated fat storage Inhibiting this enzyme helps reverse those metabolic imbalances

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