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Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

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When BPC-157 binds to VEGFR2 on endothelial cells, it triggers downstream signaling (Akt and eNOS activation) that promotes the formation of new blood vessels