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Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R (2009) Adipose tissue as a source of nicotinamide N -methyltransferase and homocysteine

In preclinical and in-vitro research environments, AOD9604 has been examined for its role in lipid metabolism signaling and cellular energy regulation mechanisms

It does not activate the hGH receptor or raise IGF1 levels, and it has no meaningful effect on blood glucose or insulin sensitivity

Numerous studies have reported that NNMT has an inhibitory effect on the aerobic metabolism of sugars and fats, and NNMT Knockdown can increase oxygen consumption, promote sugar consumption and reduce fat synthesis, but the effects of NNMT on anaerobic energy metabolism have not been reported