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Secondary endpoints included the proportion of participants achieving 5% and 10% body weight reduction, absolute weight change in kg, change in waist circumference, lipid parameters including total cholesterol, HDL, LDL, VLDL, triglycerides, and glycaemic variables such as HbA1c, fasting glucose, insulin, HOMA-IR, and -cell function

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[DOI] [PubMed] [Google Scholar] 67.Baskin DG

Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies