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The Journal of Physiology , 589(4): 963-973

Controlled clinical evaluation of enalapril in dogs with heart failure: results of the cooperative veterinary enalapril study group (the COVE study group), Journal of Veterinary Internal Medicine 9 (4): 243-252.

C3, C4, and C5 were higher in the recurrent group after 8-week follow-up, with P values 0.05 at baseline and 8-week follow-up between the first-episode and recurrent subject groups

Also, dogs with heart failure have increased levels of biomarkers of oxidative stress and a reduction in some antioxidants, particularly vitamin E (Freeman et al, 1999)

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