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These findings suggest the potential of PEA as a versatile compound for managing various pain conditions

This route bypasses the first-pass liver metabolism that limits conventional oral peptide delivery, though the pharmacokinetics differ from subcutaneous injection

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Moreover, they modulate the release of antioxidants and promote penetration through skin, thus increasing bioavailability [132,133]

[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Courtney KD, Infante JR, Lam ET, Figlin RA, Rini BI, Brugarolas J, Zojwalla NJ, Lowe AM, Wang K, Wallace EM, et al