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Have a negative impact on unborn children : A study published in Pediatric Perinatal Epidemiology found that extremely high plasma folate and vitamin B12 levels in pregnant women were associated with risk of autism spectrum disorder

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They are particularly beneficial for vegetarians and vegans (since B12 is found primarily in animal products), older adults with reduced absorption capacity, individuals with digestive conditions such as Crohn's disease or celiac disease, and anyone who has had gastric bypass surgery

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