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This L- carnitine buffering effect also extends to the potentially toxic acyl-groups, resulting either from poorly metabolized fatty acyls and from xenobiotics such as antibiotics conjugated with pivalic acid and valproate [44], or from inhibition of certain metabolic pathways for example propionic acid in propionic acidemia [45]

doi: 10.7759/cureus.27809 59 Sebastin DomingoJ

Recent studies have demonstrated that stimulants, along with the non-stimulants atomoxetine and extended-release guanfacine, are continuously effective for more than 2-year treatment periods with few and tolerable adverse effects

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