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(Royal Society of Chemistry)Cancer-targeted drug delivery systems with permeability of the blood-brain barrier (BBB) have become of great interest for the rational design of high-efficiency anticancer agents

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Most flavonoids are competitive antagonists of CD38 and 4,5-dihydroxyanthraquinone-2-carboxylic acid (RHein) is the only uncompetitive inhibitor reported to date (Table 2)[75-76]

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