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The collagen remodeling cycle completes its first full pass, and the cumulative effect of new fiber synthesis becomes visible as improved firmness, reduced sagging in the lower face and neck, and a measurable difference in skin density

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Arq Bras Endocrinol Metabol 57(3):193204 Ralli M, Angeletti D, Fiore M, DAguanno V, Lambiase A, Artico M et al (2020) Hashimotos thyroiditis: an update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation

EBioMedicine 2017, doi:10.1016/j.ebiom.2017.04.013