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However, advancements in nasal drop products have improved the dispensing system, for example: (i) by using more uniform dropper-tip geometries or flow restrictors to produce more consistent drop formation, (ii) ergonomic squeeze bottles that enable easier one-handed use, and (iii) user-friendly nozzle designs that help patients position the tip more consistently

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Of those 28 studies, only 20 studies (71%) assessed study outcomes in both sexes, and only 7 (25%) reported statistical analysis related to sex differences (Supplementary Table S1), with many studies claiming an inability to properly assess sex differences, given small sample sizes