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Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: Recommendations for a public health approach

Lastly, in the advanced stage, collagen becomes heavily cross-linked, and phenotypic changes of fibroblasts to myofibroblasts (MFBs) along with an atrophic epithelium are observed, which increases the risk for epithelial dysplasia and oral squamous cell carcinoma (OSCC) (Passi et al., 2017)

Hence, the GSH/GSSG ratio represents a marker of oxidative stress

Hubner S, Konopleva M, Zeng Z, Hoff FW, Qiu Y, Ruvolo V, Horton TM, Kornblau SM

The degenerative process itself may deplete these resident progenitor pools, impair essential EMT processes required for cell migration, or hinder the ability of migrated cells to reach their target locations [39]
